HUBUNGAN FREKUENSI DAN LAMANYA TRANSFUSI DARAH DENGAN KADAR FERRITIN PADA PASIEN TALASEMIA DI RUMAH SAKIT TK II DUSTIRA CIMAHI

Abstract

Background: Thalassemia is a hereditary disease (genetic disorder) caused by abnormalities in red blood cells which can cause sufferers to have to undergo blood transfusions as the main treatment. Repeated blood transfusions can cause a buildup of iron in the body. Objective: This study aims to determine the relationship between the frequency and duration of blood transfusions and ferritin levels in thalassemia patients at Tk.II Dustira Cimahi Hospital. Methods: This research method uses quantitative descriptive with a cross sectional approach. Respondents were taken based on inclusion criteria and a sample of 36 people was obtained. The variables studied included the frequency and duration of blood transfusions for thalassemia patients at Tk.II Dustira Cimahi Hospital on ferritin levels. Data was collected through patient medical records and questionnaires analyzed using descriptive statistical tests and correlation tests to determine significant relationships. Results: Based on the research results, ferritin levels were found to be 1000 - 5000 ng/ml for 15 respondents (42%), 5000-10,000 ng/ml for 18 respondents (50%) and >10,000 ng/ml for 3 respondents (6%). The mean ferritin level of thalassemia patients at Tk.II Dustira Cimahi Hospital in this study was 5630 ng/ml with a median value of 5280 ng/ml. Normal values for ferritin levels are men: 30-300 ng/ml, women: 17-150 ng/ml. The results of the non-parametric Spearman correlation test showed a p-value > 0.05. Conclusion: that there is no significant relationship between the frequency and duration of blood transfusions with ferritin levels. This is because respondents regularly consume iron chelating drugs.